98th Annual Meeting DOG 2000

K 771

Effect of radiotherapy of small classical subfoveolar choroidal neovascularisation (CNV) – Results after two years

A. Breyer – Pacurar1, A. Röser2, R. B. Schilcher2, E. Gerke1

Several studies on the effect of radiotherapy of choroidal neovascularisation could not demonstrate successful results. In our previous study, however, those patients with a small classical CNV ( < ¼ disc diameter, DD ) experienced no visual detoriation during one year. The following study presents the results two years after radiotherapy.

Patients and methods: Only patients with CNV in the early stage of AMD and a visual acuity of at least 20/100 were treated. The fellow eye had already suffered from visual loss due to subretinal fibrosis . 11 patients showed a CNV smaller than half a DD, with 8 of them being even smaller than one quarter DD. Radiotherapy was performed with 8x2 Gy at an linear accelerator with 18 MV over a 40° laterally to the longitudinal axis of the patient tilted field of 3,5x2,2 cm size. Follow up visits were at 3, 6, 12 and 24 month after radiation.

Results: Two years after radiotherapy 4 patients had visual improvement of more than one line. Six patients showed a stabilization and one a detoriation of two lines. Only patients with a CNV – size smaller than ¼ DD did improve, the patient with the detoriation had a CNV larger than ¼ DD but less than ½. DD.

Conclusion: Even though radiotherapy in general shows no positive effect in CNV – treatment, at least a small group of patients ( classical subfoveolar CNV, < ¼ DD ) seems to benefit from this therapy.

1 Augenklinik und 2 Klinik für Strahlentherapie, Radio – Onkologie und Nuklearmedizin, Klinikum Wuppertal GmbH, Heusnerstr. 40, D- 42283 Wuppertal, Klinikum der Universität Witten–Herdecke, Akademisches Lehrkrankenhaus der Heinrich–Heine–Universität Düsseldorf