K 771Effect of radiotherapy of small classical subfoveolar choroidal neovascularisation (CNV) Results after two years
A. Breyer Pacurar1, A. Röser2, R. B. Schilcher2, E. Gerke1
Several studies on the effect of radiotherapy of choroidal neovascularisation could not demonstrate successful results. In our previous study, however, those patients with a small classical CNV ( < ¼ disc diameter, DD ) experienced no visual detoriation during one year. The following study presents the results two years after radiotherapy.
Patients and methods: Only patients with CNV in the early stage of AMD and a visual acuity of at least 20/100 were treated. The fellow eye had already suffered from visual loss due to subretinal fibrosis . 11 patients showed a CNV smaller than half a DD, with 8 of them being even smaller than one quarter DD. Radiotherapy was performed with 8x2 Gy at an linear accelerator with 18 MV over a 40° laterally to the longitudinal axis of the patient tilted field of 3,5x2,2 cm size. Follow up visits were at 3, 6, 12 and 24 month after radiation.
Results: Two years after radiotherapy 4 patients had visual improvement of more than one line. Six patients showed a stabilization and one a detoriation of two lines. Only patients with a CNV size smaller than ¼ DD did improve, the patient with the detoriation had a CNV larger than ¼ DD but less than ½. DD.
Conclusion: Even though radiotherapy in general shows no positive effect in CNV treatment, at least a small group of patients ( classical subfoveolar CNV, < ¼ DD ) seems to benefit from this therapy.
1Augenklinik und 2 Klinik für Strahlentherapie, Radio Onkologie und Nuklearmedizin, Klinikum Wuppertal GmbH, Heusnerstr. 40, D- 42283 Wuppertal, Klinikum der Universität WittenHerdecke, Akademisches Lehrkrankenhaus der HeinrichHeineUniversität Düsseldorf