98th Annual Meeting DOG 2000

P 758

Transpupillary thermotherapy (TTT) of occult choroidal neovascularization – a pilot study

B. Fuisting, G. Richard

Introduction: Occult choroidal neovascularization (CNV) is the leading cause of blindness in exudative age-related macular degeneration.This study was performed to evaluate the possible benefit of transpupillary thermotherapy for occult CNV.

Methods: 50 patients with uni- or bilateral predominantly occult CNV were treated with TTT. Infrared light at 810 nm delivered from a infrared diode laser was used to apply spots with a size of 3000 µm for about 60 seconds duration. A complete ophthalmologic examination including visual acuity, slit-lamp biomicroscopy, funduscopy, fluorescein angiography and optical coherence tomography (OCT) was performed prior to and 3 and 6 months after the treatment.

Results: The majority of eyes showed a rapid decline of CNV activity after TTT. Retinal edema formation, assessed by OCT, decreased rapidly. In eyes with persistent CNV activity, an additional treatment was performed 3 months after first TTT. As visible on fluorescein angiography, the effect of TTT results from the occlusion of small choroidal vessels. Rare complications include the occlusion of retinal vessels. Nevertheless, visual acuity improved in 20% of eyes and remained stable in most eyes. There was a significant relief of metamorphopsia.

Discussion: A controlled multicenter study is planned to examine the efficacy, possible indications and side effects of TTT.

Eye Clinic, University Hospital Eppendorf, Martinistr.52, D–20246 Hamburg