98th Annual Meeting DOG 2000

K 699

Indocyanine–green-angiography of choroidal metastasis

L. Krause, F. Servetopoulou, N. E. Bechrakis, K. M. Kreusel

Purpose: Up to now, diagnosis of choroidal tumors is mainly based on ophthalmoscopy and ultrasound examination. Fluoresceinangiography (FA) and indocyanine-green-angiography (ICG-A) allow the identification of vascular patterns in these tumors, which could be helpful in differential diagnosis.

Aim of the study was to characterize the staining modality of choroidal metastasis with ICG-A.

Methods: 55 eyes with choroidal tumors (11 choroidal metastasis, 44 choroidal melanomas) were examined with ICG-A using the scannining laser ophthalmoscope (SLO) by Rodenstock.

In 11 patients, the diagnosis of choroidal metastasis was established by screening giving evidence for metastatic cancer (6 breast cancer, 5 lung cancer).

Results: Large tumor vessels could be identified in all tumors which characterize their staining modality. 95% of the malignant melanomas showed a blockade of the background staining in the early and late phase of ICG-A.

All cases of metastasis also showed a blockage of the background staining, but in contrast to melanoma, only a few vessels were observed. The staining pattern can be described as patchy high density staining.

Conclusions: Choroidal malignant melanoma and metastasis showed a characteristic different staining pattern in ICG-A, which may be useful in the differential diagnosis of these tumors.

Augenklink, Univ.-Klinkum Benjamin Franklin, FU Berlin, Hindenburgdamm 30, D-12200 Berlin