98th Annual Meeting DOG 2000

P 691

Transpupillary thermotherapy (TTT) of malignant choroidal melanoma

B. Fuisting

Introduction: Small choroidal melanomas or apical residual tumors are difficult to manage. The present study investigates the efficacy of TTT as anti-tumor therapy for these conditions.

Methods: Patients suffering from fluorescein angiographically proven residual activity of a malignant choroidal melanoma after radiation treatment with a ruthenium applicator or a small choroidal melanoma were treated using TTT. Infrared diode laser light (810 nm) was applied to the area of tumor vessels with a spot size of ³ 3000 µm for 60 seconds‘ duration. A complete ophthalmologic examination including fluorescein angiography was performed prior to and 3 and 6 months after the treatment.

Results: In almost all patients, a complete occlusion of the treated tumor vessels was observed within one week after treatment. In patients with persistent activity in the tumor area at 3 months, a second laser treatment was possible without any problems.

Discussion: TTT proved to be an efficient new therapeutic option for patients with an apical residual tumor or a small choroidal tumor. Up to now, none of the patients required a further brachytherapy or enucleation.

Eye Clinic, University Hospital Eppendorf, Martinistr.52, D–20246 Hamburg