98th Annual Meeting DOG 2000

K 409

The effect of topical Cyclosporin A (2%) eyedrops in atopic and vernal keratoconjunctivitis

I. Tomida, T. Schlote, M. Zierhut

Purpose: To investigate the effect of additional topical Cyclosporine A (CsA) in the treatment of atopic and vernal keratoconjunctivitis.

Material and methods: 26 patients with atopic (group 1) and 12 patients with vernal keratoconjunctivitis (without any signs of atopy; group 2) who had shown insufficient response to topical antihistamines or lodoxamide (seldom corticosteroids, n=6) before were treated additionally with CsA (2%) eyedrops t.i.d. or q.i.d. Symptoms and findings were assigned to scores (-1 to 25), depending on manifestation (itching, tears secretion, foreign body sensation, spasm of eyelid, pain) and frequency.

Results:

(selection)

Atopic K.C. (first examination)

Atopic K.C. (last examination)

Vernal.K.C (first examination)

Vernal K.C. (last examination)

Subtarsal Papillae

96,2 %

77,3% reduced

4,5 % none

100 %

80% reduced

20 % none

Chronic Conjunctivitis

92,3 %

50 % reduced

22,7 % none

91,7 %

50% reduced

40 % none

Blepharo-spasmus

34,6 %

100 % none

25,0 %

90,0 % none

Trantas dots

34,6 %

30,8% reduced

69,2 % none

25,0 %

40% reduced

60 % none

The median score for symptoms could be reduced from 16.05 (± 4.04) on first examination to 9.08 (± 2.94) on last examination (group 1), in group 2 from 13.58 (± 3.42) to 8.10 (± 2.47) on last examination.

Conclusion: Additional CsA (2%) eyedrops have been shown to be effective in the treatment for atopic and vernal keratoconjunctivitis, as they improved considerably the condition of these patients.

Department of Ophthalmology I; University Tuebingen, Schleichstr.12-16, D - 72076 Tuebingen



Back