Transscleral optical coherence tomography first experimental and clinical results
H. Hoerauf, R. Gordes, C. Scholz, R. Engelhardt, J. Winkler, R. Birngruber
Background: To evaluate the potentials of OCT using longer wavelength to penetrate highly scattering tissues thus visualizing the chamber angle and the ciliary body.
Methods: OCT-images were generated by an experimental prototype using as light source a superluminiscent diode with a wavelength of 1310 nm and a scan frequency of 60 Hz. The number of lateral scans was variable in a range from 100 to 400. OCT-images were taken in enucleated human eyes by a handheld applicator. First in vivo images were generated in healthy volunteers with a slitlampadapted prototype.
Results: Infrared-OCT was able to penetrate the sclera. The anterior chamber angle could be visualized completely, thereby allowing perpendicular and reproducible measurements. Furthermore, the ciliary body could be identified. It was not possible to penetrate the iris pigment epithelium.
Conclusion: The use of long wavelength-OCT allows penetration of the sclera, thus providing complete visualization of the chamber angle and ciliary body. It may represent an interesting noninvasive alternative to ultrasound biomicroscopy.
University Eye Clinic, Ratzeburger Allee 160, D - 23538 Lübeck