98th Annual Meeting DOG 2000

P 278

Therapy of retinal neovascularisations with Interferon a 2a

M. Zierhut1, I. Koetter2, C. M. E. Deuter, 1 T. Schlote1, N. Stuebiger1

Introduction: One of the main problems in occlusive retinal vasculitis is the induction of retinal neovascularisations induced by secondary retinal ischemia. We already demonstated the antiinflammatory effects of Interferon a 2a (IFN a 2a) in the therapy of occlusive vasculitis due to Behçet´s disease (BD) (Koetter et al. 1998). Now we present the antiangiogenic character of IFN a 2a.

Patients and Methods: Three patients with severe neovascularisations of the optic disc recieved a therapy with IFN a 2a, starting with 6 Mill IU/day, slowly tapered down. Two of these patients have had ocular BD, the other patient had developed panuveitis with occlusive vasculitis of unknown origin.

Results: Under treatment with IFN a 2a we induced remission of posterior uveitis in all three patients. In addition we observed in the two patients with BD complete regression of the retinal neovascularisations in between 3 weeks. In the patient with occlusive retinal vasculitis of unknown origin we achieved massive regression of the optic disc neovascularisations.

Conclusion: In the interferons antiinflammatory effects, and, in additon, antiangiogenetic effects are known. IFN a 2a seems to reduce ocular inflammation and, consecutively, secondary induced retinal neovascularisation.

To our knowledge these are the first three cases describing drug induced antiangiogenesis in retinal neovascularisations due to occlusive retinal vasculitis.

1University Eye Hospital Tuebingen, Schleichstrasse 12-16, D-72076 Tuebingen
2University Medical Clinic Tuebingen, Otfried-Mueller-Strasse 10, D-72076 Tuebingen