98th Annual Meeting DOG 2000

P 237

Clinical investigation of corneal contact time of Liposicâ AT in patients with and without Keratoconjunctivitis sicca

S. Torens, E. Berger, J. Stave, R. Guthoff

Background: Keratoconjunctivitis sicca is one of the most often diagnosed diseases in ophthalmology. Tear substitution by means of artificial tears has been common therapy. The corneal contact time of artificial tears is important for the duration of patients relief of complaints. The aim of this study was to measure and compare the corneal contact time of LIPOSICâ AT after single dose application in patients with and without dry eye syndrome.

Patients / Methods: In 20 patients with and without dry eye syndrome we measured the corneal contact time by evaluation of image sequences by using the modified Confocal –Scanning-Laser-Ophthalmoscope (Fa. Zeiss). ISchirmer-Test II was below 10 mm / 5 min and Break-Up-Time (BUT) was below 10 seconds, the patient was assigned to have Keratoconjunctivitis sicca. The effect of single dose application was shown by NIBUT (Non-Invasive-Break-Up-Time).

Results: A prolonged corneal contact time of LIPOSICâ AT was demonstrated in patients with dry eye syndrome in comparison to patients without this disease. In patients with dry eye syndrome a prolongation of NIBUT was shown.

Discussion: The Break-Up-Time (BUT) of the preocular tear film is a clinically reliable evaluation of the tear film stability, but is discussed controversially. Non-invasive-break-up-time (NIBUT) is the more reliable parameter. The prolonged corneal contact time due to one time application of LIPOSICâ AT caused extention of NIBUT of the treated eye, which suggests that the longer effect of duration is caused by stabilisation of the precorneal tear film. This is of clinical importance for the relief of complaints and the rate of application for the patient.

University Department of Ophthalmology, Doberaner Str. 140, D-18055 Rostock