V 195Multifocal electroretinography in patients with nonexudative and exudative age related macular degeneration
B. Jurklies, M. Weismann, N. Bornfeld
To objectively investigate retinal function in patients with age-related macular degeneration (AMD) using multifocal electroretinography.
Methods: Based on the findings of fluorescein angiography and ophthalmoscopy, 81 eyes of patients with non exudative AMD and 55 Patients with exudative AMD were divided into groups as follows: Patients with nonexudative AMD were classified in group I representing drusen and geographic atrophy and group II as having drusen. Patients with exudative AMD were classified in group I, classic, group II occult, and group III both classic and occult choroidal neovascularization (CNV). Using a pseudorandom m-sequence, 103 locations within the central 25x30° were stimulated (maximal luminance of 200 cd/sqm and 300 cd/sqm) concurrently using the VERIS-System (EDI, San Francisco). The response components were extracted for each stimulated retinal location. Mean amplitudes and implicit times (1st order kernel) of ring 1 (center) to 6 (periphery) with different eccentricity were evaluated and compared to a normal control group. Normalized amplitudes were compared to each other for each group.
Results: Amplitudes were reduced and implicit times prolonged in all of the AMD groups compared to the normal control group. The changes were more evident in nonexudative AMD in group I than in group II. In exudative AMD the parameters were most affected in group III. The changes were more evident in the central stimulated fields than in periphery.
Conclusions: Amplitudes and implicit times (1st order kernel) were affected depending on the eccentricity and localisation of the lesion. This may at least in part correlate with the activity and severity of the lesion in exudative and nonexudative AMD, respectively.
Universitäts-Augenklinik, Hufelandstraße 55, 45122 Essen, Germany
Supported by Deutsche Forschungsgemeinschaft (DFG), grant Ju 1-1