98th Annual Meeting DOG 2000

K 135

Histopathology of silicone oil keratopathy

W. Sekundo, L. Hesse, J. Schmidt, P. Kroll

Purpose: To evaluate the histopathological features of clinically diagnosed silicone oil induced keratopathy.

Material and methods: We reviewed the registry of the ophthalmopathological laboratory at the University of Marburg with respect to the following histopathological diagnosis made in the past ten years: "bullous keratopathy", "endothelial-epithelial corneal decompensation", "band keratopathy" and "endothelial degeneration". These specimens were cross-checked with appropriate medical records. Finally, 6 specimens were identified, were a clinical diagnosis of silicone oil induced keratopathy has been made. All 6 specimens were examined by light microscopy using H&E and PAS stains.

Results: A long-standing bullous keratopathy was seen in 4 out of 6 specimens. A corneal ulcer was present in another cornea. The corneal stroma showed various degree of hydration. In all but one corneal button, where guttata-like excrescences were observed, the anterior part of DescemetÂ’ membrane was continuos and unremarkable. A posterior collagenous layer was identified in the adult portion of DescemetÂ’ membrane in all specimens examined. Endothelial cell loss and degeneration was present in all specimens. The endothelial cell density varied between 0 and 5 cells per high power field (x 400).

Conclusion: Posterior collagenous layer associated with degenerating endothelium appears to be a typical histopathological feature in silicone oil induced keratopathy. Possible mechanisms will be discussed.

Department of Ophthalmology, Philipps University of Marburg, Robert-Koch-Str. 4, D-35037 Marburg