98th Annual Meeting DOG 2000

K 119

Penetrating keratoplasty with grafts from pseudophakic donors

J. Best, D. Böhringer, H. Spelsberg

Background: Pseudophakia is considered as an exclusion criterion for cornea donation. The aim of this retrospective study was to investigate the clinical outcome and prognosis of penetrating keratoplasty with grafts from pseudophacic donors.

Patients and methods: 2374 corneas were collected and cultured in the Lions- Cornea Bank of NRW from 1995 to 1999. 105 corneas of these originated from pseudophakic donors: 1996:1 (<1%), 1997: 18 (5%), 1998: 21 (4%) and 1999: 65 (9%). 14 grafts from pseudophakic donors were transplanted, mostly in à chaud situations. 64 percent of these cases have been considered high risk. The mean age of the pseudophacic donors was 75 years, that of the other donors 61. The homogeneity of the cell pattern and the endothelial cell density were evaluated after explantation, after 7 days in organ culture and the morning before transplantation. Postoperatively the recipients were followed prospectively and especially the endothelial cell density was recorded.

Results: The recipients of the grafts from pseudophacic donors had a mean endothelial cell density of 1650 cells/mm2 after a mean follow-up time of 5 months. The control group was followed 18 months in mean and had a mean endothelial cell density of 1603 cells/mm2. No graft failure in the group of the recipients of the grafts from pseudophacic donors was observed till now despite the unfavorable risk profile (more à chaud cases than in the control group).

Conclusion: The rate of pseudophakic cornea donors rose considerably during the last years. Our clinical results reveal no reason to regard pseudophakia as a principal contraindication for cornea donation, critical endothelial evaluation provided.

Lions Hornhautbank NRW und Augenklinik, Heinrich-Heine-Universität, Moorenstr. 5, D-40225 Düsseldorf